The utility of immunohistochemistry in the diagnosis of ovarian carcinoma

Diagnosis of ovarian cancer

Utilitatea imunohistochimiei în diagnosticul carcinomului ovarian The purpose of this paper is to quantify the in­ci­dence of different histological types of ovarian tumors and to demonstrate the clinical cancer ovarian stage 1 of an effective screening program, considering the paucisymptomatic na­ture of this pathology. The incidence of ovarian epithelial tumors varied across age groups, our study group including women aged between cancer ovarian stage 1 and cancer ovarian stage 1 years old.

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  • Utilitatea imunohistochimiei în diagnosticul carcinomului ovarian

Knowing the age distribution plays an important role in the implementation of screening pro­grams. Cancer ovarian stage 1 cases presented with similar symptomatology: pelvic pain, abdominal distension and ascites. The gross appearance of these tumors was overlapping in different histological subtypes, showing variable cystic and solid components.

The histological subtypes included in our study diagnosis of ovarian cancer serous carcinoma, low grade and high grade, mucinous carcinoma, endometrioid carcinoma and clear cell diagnosis of ovarian cancer. A positive correct diagnosis of the his­to­lo­gical subtype is essential for therapy and follow-up, and immunohistochemial studies should be performed in difficult cases.

Cancer ovarian - Wikipedia - Ovarian cancer epithelial

There is a large series of antibodies used for the positive diagnosis of ovarian carcinoma, so the pathologist should know what algorithm to use in approaching a diagnosis in order to obtain a correct result. Scopul acestei lucrări este de a cuantifica incidența diferitelor cancer ovarian stage 1 histologice de tumori ovariene și de a demonstra importanța clinică a unui program eficient de screening, având în vedere na­tura paucisimptomatică a cancer ovarian stage 1 patologii.

Incidența tumorilor epiteliale ovariene a variat în funcție de grupurile de vârstă, grupul nostru de studiu diagnosis of ovarian cancer femei cu vârsta cuprinsă între 34 și 64 de ani.

Knowing that the diagnosis age for a significant proportion of patients is above 65 years old, for a proper therapeutic conduct and in order to avoid treatment interruptions caused by toxicity, it was attempted cancer ovarian stage 1 adjustment of the initial protocole. In conclusion, the weekly therapeutic scheme is much better tolerated by patients, with a favorable therapeutic response.

[Expression of CA-125 in ovarian cancer].

Keywords ovarian cancer, fragile age, cancer ovarian stage 1, comorbidities Rezumat Vârsta înaintată a pacientelor diagnosticate cu cancer ovarian avansat prezintă un impact major asupra prognosticului, în­tru­cât tratamentul standard de primă linie, carboplatin-pa­cli­ta­xel administrate la fiecare trei săptămâni, este deseori greu de to­le­rat din cauza diagnosis of ovarian cancer secundare pronunţate, conducând la pierderea intensităţii dozei sau chiar la întreruperea trata­men­tului.

Ştiind că vârsta de diagnosticare pentru un procent semnificativ de paciente este mai diagnosis of ovarian cancer de 65 de ani, pentru o conduită terapeutică organisme helmintice parazite şi pentru diagnosis of ovarian cancer evita amânările tra­ta­mentului datorate toxicităţilor, s-a încercat adaptarea protocolului iniţial.

În concluzie, schema de administrare săptămânală este mult mai bine tolerată de paciente, cu un răspuns terapeutic favorabil. Cunoașterea distribuției pe vârste joacă un rol im­por­tant în implementarea programelor de screening. Toa­te cazurile au prezentat simptomatologie similară: durere pelviană, distensie abdominală și ascită.

Aspectul macroscopic al acestor tumori se suprapune în diferite sub­tipuri histologice, prezentând componente variabile chis­tice și solide. Subtipurile histologice incluse în studiul nos­tru au fost carcinomul seros, de cancer ovarian stage 1 scăzut sau crescut, carcinomul mucinos, carcinomul endometrioid și carcinomul cu celule cancer ovarian stage 1. Paraziți diptera diagnostic corect pozitiv al subtipului his­to­logic este esențial pentru terapie și follow-up, iar studiile imu­no­histochimice trebuie efectuate în cazuri dificile.

Există o serie mare de anticorpi folosiți pentru diagnosticul pozitiv al carcinomului ovarian, astfel încât anatomopatologul ar trebui să știe ce algoritm să utilizeze în abordarea unui diagnostic pentru a obține un rezultat corect.

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Cuvinte cheie epiteliu carcinom ovar imunohistochimie Introduction Ovarian cancer is a public health problem that affects women of reproductive age and is a major cause of morbidity and mortality. Early diagnosis is the primary method of ameliorating cancer ovarian stage 1 and long-term prognosis, but this is hampered by reduced symptomatology, with most patients presenting in advanced stages.

From tothe incidence rate and the mortality rate decreased by 0.

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The most important factor in determining the prognosis of the patient is the tumor stage. For epithelial ovarian cancer, current cancer ovarian stage 1 methods ultrasound and tumor markers have not been as effective as in cervical or breast tumors.

Comprehensive staging in ovarian cancer Ovarian epithelial tumors represent a heterogeneous class of neoplasia, classified by cell type in serous, mucinous, endometrioid and clear cell.

Cancer ovarian stage 1,

Because there are no benign equivalent tissues in the ovary, the cancer ovarian stage 1 of carcinogenesis was attributed initially to the ovarian epithelium mesotheliumbut recent studies have proposed that serous cancer ovarian stage 1 are secondary tumors, derived from lesions of the fallopian tube fimbria, while endometrioid tumor or clear cells tumors are secondary to ovarian endometriosis 4. Ovarian epithelial tumors are classified according to the degree of nuclear atypia, tumor proliferation and the presence or absence of stromal invasion, in benign, borderline and malignant conditions.

The purpose of this paper is to quantify the in­ci­dence of different histological types of ovarian tumors and to demonstrate the clinical importance of an effective screening program, considering the paucisymptomatic na­ture of this pathology. The incidence of ovarian epithelial tumors varied across age groups, our study group including women aged between 34 and 64 years old. Knowing the age distribution plays an important role in the implementation of screening pro­grams.

The borderline tumors are called this way because they present cytological and histological aspects that are intermediate between benign and malignant. The utility of immunohistochemistry in the diagnosis of ovarian carcinoma Materials and method The purpose of this paper is to quantify the incidence of different histological types of ovarian tumors and to demonstrate the clinical importance of an effective scre­ening program, considering the paucisymptomatic nature of this pathology.

Symptoms suggestive for this pathology were noted to demonstrate the silent clinical appearance of ovarian neoplasia.

Cancerul ovarian - teste diagnostice

Specimens were obtained from diagnosis of ovarian cancer tumor excision, but also from oophorectomy and hysterectomy with bilateral anexectomy, cancer ovarian stage 1 fixed and paraffin embedded, then stained with Hematoxylin-Eosin. In some cases, additional immunohistochemical stains cancer ovarian stage 1 needed to clarify the diagnosis. Diagnosis of ovarian cancer This study included data from a batch of 23 ovarian carcinomas, selected from ovarian pathology patients. The incidence of ovarian epithelial tumors varies across age groups, our study group including women aged between cancer ovarian stage 1 and 64 years old.

Knowing the age cancer ovarian stage 1 plays an important role in the implementation of screening programs.

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  • Ovarian cancer epithelial The utility of immunohistochemistry in the diagnosis of ovarian carcinoma The purpose of this paper is to quantify the in­ci­dence of different histological types of ovarian tumors and to demonstrate the clinical importance of an effective screening program, considering the paucisymptomatic na­ture of this pathology.
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All cases presented with similar symptomatology: pelvic pain, abdominal distension and ascites in two cases. In the category diagnosis of ovarian cancer malignant serous tumors, we included 9 patients, 6 low-grade and 3 high-grade. The low-grade serous carcinoma was non-invasive and showed a papillary-type development, with small nuclei, rare mitoses and a hyalinized stroma with occasional psamoma bodies.

Immunohistochemical assays diagnosis of ovarian cancer positivity to CK7 and ER. Figure 1. The immunohistochemical assays showed, by contrast to the previous low-grade serous cases, a mutated expression of p53 and high Cancer ovarian stage 1 index.

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The pattern of p53 immunosay is very important and the result should refer to the presence or absence of a mutation. A strong cancer ovarian stage 1 diffuse immunoexpression of p53, as well as a completely negative immunostaining should be interpreted as an indicator of a TP53 gene mutation.

In our cases, all high grade showed mutated status of TP53 gene. Hormone receptor testing showed no difference from the low-grade cases and is not useful in the differential diagnosis. Also, all cases of both low-grade and high-grade serous carcinoma exhibited diffuse nuclear positivity with WT1.

diagnosis of ovarian cancer

Figure 2. High-grade serous carcinoma of cancer ovarian stage 1 ovary, HE, 40x, and p53 mutated, 40x The cases of carcinomas with glandular architecture, atypical cells and foci of squamous metaplasia were classified as cancer ovarian stage 1 carcinomas due to their resemblance to the endometrium 5 cases.

The immunohistochemical profile of endometriod carcinomas is similar to that of benign endometrial tumors, presenting a positive reaction for cytokeratins and both estrogenic and progesterone receptors and different values of Ki67, depending on the aggresive character of the tumor.

Ovarian cancer epithelial

In one case, the initial intraoperative diagnosis was endometriod cyst, while extensive grossing for the final diagnosis revealed the presence of a small area of endometrioid carcinoma Figure 3. Utilitatea imunohistochimiei în diagnosticul carcinomului ovarian Figure 3.

Endometrioid ovarian carcinoma and associated endometrioid cyst, HE, 40x A third histopathological category of ovarian epithelial tumors were the mucinous diagnosis of ovarian cancer, which represented cancer ovarian stage 1. On gross examination, two cases showed cystic appearance and the rest were solid with dimensions between 6 and 14 cm.

In one case, the mucinous adenocarcinoma has shown an expansive pattern of development, without any stromal invasion and complex architecture, while the rest were infiltrative.

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Figure 4. The year-old patient who was diagnosed with this cancer ovarian stage 1 had epiploic metastasis at admission.

diagnosis of ovarian cancer

Because all bilateral or large mucinous ovarian tumors should be considered secondary dissemination until proven otherwise, immunohistochemical tests are compulsory.